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DeCS
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Descriptor English:
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Receptors, Thrombin
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Descriptor Spanish:
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Receptores de Trombina
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Descriptor Portuguese:
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Receptores de Trombina
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Synonyms English:
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Peptide, TRAP
Receptor, Thrombin
TRAP Peptide
Thrombin Receptor
Thrombin Receptor Activating Peptide Ligand
Thrombin Receptor Activating Peptides
Thrombin Receptor Activator Peptide
Thrombin Receptors
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Tree Number:
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D12.776.395.550.625.800
D12.776.543.550.625.800
D12.776.543.750.695.875
D12.776.543.750.705.675.892
D12.776.543.750.750.850
D12.776.543.750.792.500
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Definition English:
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A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity. |
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History Note English:
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1994; use THROMBIN RECEPTOR (NM) 1981-1993; for TRAP PEPTIDE use RECEPTORS, THROMBIN (NM) 2000-2003
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Allowable Qualifiers English:
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Record Number:
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31095
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Unique Identifier:
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D018179
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Occurrence in VHL:
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Similar:
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DeCS
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